成人结核性脑膜炎强化治疗

Tuberculousmeningitisisoftenlethal.Earlyantituberculosistreatmentandadjunctivetreatmentwithglucocorticoidsimprovesurvival,butnearlyonethirdofpatientswiththeconditionstilldie.WehypothesizedthatintensifiedantituberculosistreatmentwouldenhancethekillingofintracerebralMycobacteriumtuberculosisorganismsanddecreasetherateofdeathamongpatients.

Weperformedarandomized,double-blind,placebo-controlledtrialinvolvinghumanimmunodeficiencyvirus(HIV)–infectedadultsandHIV-uninfectedadultswithaclinicaldiagnosisoftuberculousmeningitiswhowereadmittedtooneoftwoVietnamesehospitals.We







































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